DSC2

Across TCGA patient cohorts, DSC2 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,632 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DSC2-associated proteins across cancer lineages are SERPINB5, VPS4B, and JUP. Each is linked with DSC2 in more than 6 cancer types. Because this analysis shows association rather than direction, both DSC2-to-partner and partner-to-DSC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DSC2 versus SERPINB5 in COAD, with a Pearson correlation of 0.37.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DSC2→partner) and Y-score (partner→DSC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	SERPINB5 →	+1.353	+0.691	.001	.002	3	7
HNSC	VPS4B →	+0.310	+1.009	<.001	<.001	3	7
LSCC	JUP →	+0.808	+1.155	<.001	<.001	3	6
HNSC	TUBA1C →	+0.484	+1.275	<.001	.002	3	6
LSCC	DSC2_S873 →	+1.276	+1.613	<.001	<.001	3	5
LSCC	DSP →	+0.986	+1.229	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,632 associations by consensus.

DSC2 vs SERPINB5 — COAD

Explore this scatter interactively →