DSC2

Across TCGA patient cohorts, DSC2 protein abundance is significantly associated with the RNA expression of many other genes, with 20,793 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DSC2-associated genes across cancer lineages are DSG2, PERP, and DSC1. Each is linked with DSC2 in more than 6 cancer types. Because this analysis shows association rather than direction, both DSC2-to-partner and partner-to-DSC2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DSC2 versus DSG2 in LUAD, with a Pearson correlation of 0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSC2→partner) and Y-score (partner→DSC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DSG2 →	+0.964	+0.615	<.001	<.001	3	7
LSCC	PERP →	+1.018	+0.776	<.001	<.001	3	6
HNSC	DSC1 →	+1.893	+0.695	<.001	<.001	3	6
HNSC	DSCAS →	+0.520	+0.685	<.001	<.001	3	6
UCEC	PLA1A →	-1.120	-0.542	<.001	<.001	3	5
BRCA	SUSD3 →	-1.932	-0.821	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,793 associations by consensus.

DSC2 vs DSG2 — LUAD

Explore this scatter interactively →