DSC2

Across TCGA patient cohorts, DSC2 mutation is significantly associated with the RNA expression of many other genes, with 3,527 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DSC2-associated genes across cancer lineages are ACTG1, RPL23AP82, and SF3B3. Each is linked with DSC2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DSC2-to-partner and partner-to-DSC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACTG1 grouped by DSC2-low versus DSC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSC2→partner) and Y-score (partner→DSC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACTG1 →	+0.432	+2.946	.007	<.001	3	3
UCEC	RPL23AP82 →	+0.546	+2.148	<.001	<.001	3	3
UCEC	SF3B3 →	+0.466	+3.128	.001	<.001	3	3
UCEC	IFRD2 →	+0.482	+2.458	<.001	.001	3	3
UCEC	FCF1P2 →	+0.382	+1.828	.004	.002	3	3
UCEC	CRYBB2P1 →	+0.434	+2.158	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,527 associations by consensus.

ACTG1 by DSC2 expression — UCEC

Explore this box plot interactively →