DSC1

Across TCGA pan-cancer cohorts, DSC1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DSC1 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DSC1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DSC1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and LSCC are the cancer types where DSC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.913	0.779	.011	11	view →
UCEC	OS	Median	All	1.000	0.723	.028	8	view →
LSCC	OS	Quartile	All	0.725	0.997	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DSC1–HNSC (OS)

Open the HNSC breakdown →