DSC1

Across TCGA patient cohorts, DSC1 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DSC1-associated genes across cancer lineages are STAT3_pY705, INPP4B, and PCNA. Each is linked with DSC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DSC1-to-partner and partner-to-DSC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by DSC1-low versus DSC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSC1→partner) and Y-score (partner→DSC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.329	-1.716	<.001	.003	3	3
UCEC	INPP4B →	-0.266	-1.847	.011	.007	3	3
UCEC	PCNA →	+0.223	+2.415	.001	.002	3	3
UCEC	ATM →	-0.442	-1.687	.002	.040	3	3
UCEC	Cyclin-B1 →	+0.661	+2.321	<.001	<.001	3	2
LUAD	Cyclin-E2 →	+0.175	+2.824	.024	.036	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

STAT3_pY705 by DSC1 expression — UCEC

Explore this box plot interactively →