DSC1

Across TCGA cell cohorts, DSC1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DSC1-associated genes across cancer lineages are P2RY13, USP17L22, and OR6P1. Each is linked with DSC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DSC1-to-partner and partner-to-DSC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, P2RY13 grouped by DSC1-low versus DSC1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSC1→partner) and Y-score (partner→DSC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	P2RY13 →	+0.005	+3.684	<.001	.006	3	1
BLOOD_Lymphoma	USP17L22 →	+0.015	+4.058	<.001	.009	3	1
BLOOD_Leukemia	OR6P1 →	+0.016	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR2A5 →	+0.032	+4.922	<.001	.009	3	1
BLOOD_Leukemia	OR2F2 →	+0.023	+6.569	<.001	<.001	3	1
LUNG_NSCLC_LUAD	GNG8 →	+0.299	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

P2RY13 by DSC1 expression — SKIN

Explore this box plot interactively →