DRP2

Across TCGA patient cohorts, DRP2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DRP2-associated genes across cancer lineages are A-Raf_pS299, FOXO3a_pS318_S321, and JNK2. Each is linked with DRP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DRP2-to-partner and partner-to-DRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by DRP2-low versus DRP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DRP2→partner) and Y-score (partner→DRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.102	-1.514	.002	.014	3	2
UCEC	FOXO3a_pS318_S321 →	-0.081	-1.142	.022	.048	3	2
UCEC	JNK2 →	+0.167	+2.026	.003	.004	3	2
UCEC	MEK1 →	+0.452	+4.247	<.001	<.001	3	2
UCEC	MSH2 →	-0.198	-1.636	.002	.009	3	2
UCEC	PCNA →	+0.225	+1.398	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

A-Raf_pS299 by DRP2 expression — UCEC

Explore this box plot interactively →