DROSHA

Across TCGA pan-cancer cohorts, DROSHA mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DROSHA data layer compared with 28 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher DROSHA mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DROSHA expression acts as an unfavorable survival marker, although some lineages such as GBM and HNSC show a favorable association.

GBM, HNSC, and LSCC are the cancer types where DROSHA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	0.651	0.466	.005	6	view →
HNSC	DFS	Median	IV	0.889	0.407	.042	2	view →
LSCC	DFS	Median	II,III,IV	0.451	0.877	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DROSHA–GBM (OS)

Open the GBM breakdown →