DRGX

Across TCGA patient cohorts, DRGX mutation is significantly associated with the RNA expression of many other genes, with 3,846 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DRGX-associated genes across cancer lineages are RNU6-1017P, AP3S2, and MRPL10. Each is linked with DRGX in more than 1 cancer types. Because this analysis shows association rather than direction, both DRGX-to-partner and partner-to-DRGX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1017P grouped by DRGX-low versus DRGX-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DRGX→partner) and Y-score (partner→DRGX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-1017P →	+0.379	+4.516	<.001	.009	3	2
UCEC	AP3S2 →	+0.354	+3.375	.001	.004	3	2
UCEC	MRPL10 →	+0.372	+3.180	.008	<.001	3	2
UCEC	VDAC2 →	+0.576	+4.258	.001	<.001	3	2
UCEC	HIF1AN →	+0.357	+3.609	.004	.001	3	2
UCEC	ZFYVE19 →	+0.451	+2.931	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,846 associations by consensus.

RNU6-1017P by DRGX expression — COAD

Explore this box plot interactively →