DRG2

Across TCGA patient cohorts, DRG2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DRG2-associated genes across cancer lineages are FASN, JNK_pT183_Y185, and PCNA. Each is linked with DRG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DRG2-to-partner and partner-to-DRG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by DRG2-low versus DRG2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DRG2→partner) and Y-score (partner→DRG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.393	+2.000	.026	.032	3	1
UCEC	JNK_pT183_Y185 →	-0.220	-3.459	.003	.005	2	2
UCEC	PCNA →	+0.205	+2.000	.035	.032	3	1
UCEC	ASNS →	+0.384	+2.459	.018	.019	3	1
UCEC	Cyclin-B1 →	+0.631	+3.321	.012	.010	3	1
UCEC	p62 Lck ligand →	+0.385	+2.700	.008	.006	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

FASN by DRG2 expression — UCEC

Explore this box plot interactively →