DRG2

Across TCGA cell cohorts, DRG2 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DRG2-associated genes across cancer lineages are BVES, GJA10, and SULT6B1. Each is linked with DRG2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DRG2-to-partner and partner-to-DRG2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BVES grouped by DRG2-low versus DRG2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DRG2→partner) and Y-score (partner→DRG2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BVES →	+0.375	+2.577	.005	.007	3	1
LARGE_INTESTINE	GJA10 →	+0.039	+3.310	<.001	<.001	3	1
LARGE_INTESTINE	SULT6B1 →	+0.021	+2.977	<.001	.006	3	1
LARGE_INTESTINE	HPGDS →	+0.025	+3.035	<.001	.003	3	1
LARGE_INTESTINE	SGSM1 →	+0.612	+3.302	<.001	.008	3	1
LARGE_INTESTINE	KRT24 →	+0.007	+2.777	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

BVES by DRG2 expression — LARGE_INTESTINE

Explore this box plot interactively →