Across TCGA patient cohorts, DRG1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DRG1-associated genes across cancer lineages are 14-3-3_beta, A-Raf_pS299, and ACVRL1. Each is linked with DRG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DRG1-to-partner and partner-to-DRG1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DRG1→partner) and Y-score (partner→DRG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.156	-2.295	<.001	.033	3	1
UCEC	A-Raf_pS299 →	-0.182	-2.999	.001	.035	3	1
UCEC	ACVRL1 →	-0.184	-2.986	.003	.035	3	1
UCEC	JNK2 →	+0.312	+3.700	<.001	.001	3	1
UCEC	MEK1 →	+0.361	+3.321	.034	.010	3	1
UCEC	Rictor_pT1135 →	-0.126	-3.169	.008	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

DRG1 survival (RNA) · tumor vs normal (RNA) · all DRG1 data types