DRD4

Across TCGA patient cohorts, DRD4 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DRD4-associated genes across cancer lineages are RNU7-90P, RPL23AP54, and MIR3166. Each is linked with DRD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DRD4-to-partner and partner-to-DRD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-90P grouped by DRD4-low versus DRD4-high in THCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DRD4→partner) and Y-score (partner→DRD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	RNU7-90P →	+0.948	+5.377	<.001	.005	3	1
THCA	RPL23AP54 →	+0.111	+5.250	<.001	.006	3	1
THCA	MIR3166 →	+0.452	+6.017	<.001	.002	3	1
THCA	RPS29P30 →	+0.381	+6.617	<.001	.001	3	1
THCA	TEX37 →	+0.059	+5.078	.008	.008	3	1
THCA	TBC1D3P4 →	+0.041	+5.921	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

RNU7-90P by DRD4 expression — THCA

Explore this box plot interactively →