DRD4

Across TCGA cell cohorts, DRD4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,228 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible DRD4-associated GO terms across cancer lineages are Adenylate cyclase-inhibiting dopamine receptor signaling pathway, Calcium-independent cell-matrix adhesion, and Positive regulation of intracellular steroid hormone receptor signaling pathway. Each is linked with DRD4 in more than 13 cancer types. Because this analysis shows association rather than direction, both DRD4-to-partner and partner-to-DRD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Adenylate cyclase-inhibiting dopamine receptor signaling pathway grouped by DRD4-low versus DRD4-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DRD4→partner) and Y-score (partner→DRD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Adenylate cyclase-inhibiting dopamine receptor signaling pathway →	-0.180	-0.296	.002	<.001	3	14
BONE	Calcium-independent cell-matrix adhesion →	+0.210	+0.297	<.001	<.001	3	12
OESOPHAGUS	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.152	+0.329	<.001	<.001	3	11
OESOPHAGUS	Protein deacylation →	+0.107	+0.487	.001	.001	3	11
OESOPHAGUS	Methylglyoxal catabolic process →	+0.180	+0.341	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Membrane raft distribution →	-0.180	-0.300	<.001	.005	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,228 associations by consensus.

Adenylate cyclase-inhibiting dopamine receptor signaling pathway by DRD4 expression — LARGE_INTESTINE

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