DRD3

Across TCGA cell cohorts, DRD3 RNA expression is significantly associated with the mutation status of many other genes, with 119 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DRD3-associated genes across cancer lineages are PDZD2, KMT2A, and TRPC7. Each is linked with DRD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DRD3-to-partner and partner-to-DRD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDZD2 grouped by DRD3-low versus DRD3-high in PANCREAS.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DRD3→partner) and Y-score (partner→DRD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PDZD2 →	+4.614	+0.005	.004	<.001	3	2
CNS	KMT2A →	+2.289	+0.012	.009	<.001	3	2
CNS	TRPC7 →	+3.459	+0.021	.006	<.001	3	2
URINARY_TRACT	CCDC40 →	+4.087	+0.017	.009	<.001	3	1
URINARY_TRACT	PCSK1 →	+5.087	+0.023	.004	<.001	3	1
URINARY_TRACT	EXOC3L1 →	+4.087	+0.017	.009	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 119 associations by consensus.

PDZD2 by DRD3 expression — PANCREAS

Explore this box plot interactively →