DRD3

Across TCGA cell cohorts, DRD3 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible DRD3-associated genes across cancer lineages are FLG2, SLC17A2, and CNPY1. Each is linked with DRD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DRD3-to-partner and partner-to-DRD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FLG2 grouped by DRD3-low versus DRD3-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DRD3→partner) and Y-score (partner→DRD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	FLG2 →	+0.163	+3.491	<.001	.008	3	1
OVARY	SLC17A2 →	+0.013	+3.700	<.001	.005	3	1
OVARY	CNPY1 →	+0.090	+3.700	<.001	.005	3	1
OVARY	OR4D6 →	+0.010	+4.222	<.001	.006	3	1
OVARY	LCE1D →	+0.036	+4.222	<.001	.006	3	1
LUNG_NSCLC_LUAD	CHP2 →	+0.185	+3.793	.006	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

FLG2 by DRD3 expression — LUNG_SCLC

Explore this box plot interactively →