DRD2

Across TCGA patient cohorts, DRD2 mutation is significantly associated with the RNA expression of many other genes, with 4,779 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DRD2-associated genes across cancer lineages are INCENP, RDXP1, and BTBD10. Each is linked with DRD2 in more than 3 cancer types. Because this analysis shows association rather than direction, both DRD2-to-partner and partner-to-DRD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INCENP grouped by DRD2-low versus DRD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DRD2→partner) and Y-score (partner→DRD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INCENP →	+0.464	+1.815	.003	.002	3	4
HNSC	RDXP1 →	+0.043	+4.010	<.001	.006	3	4
UCEC	BTBD10 →	+0.509	+1.675	<.001	<.001	3	3
UCEC	LIN7C →	+0.517	+1.653	<.001	<.001	3	3
SKCM	SSRP1 →	+0.439	+1.957	.001	<.001	3	3
UCEC	EIF4E →	+0.406	+3.191	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,779 associations by consensus.

INCENP by DRD2 expression — UCEC

Explore this box plot interactively →