DRD2

Across TCGA patient cohorts, DRD2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DRD2-associated genes across cancer lineages are IGFBP2, Annexin-1, and Caspase-8. Each is linked with DRD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DRD2-to-partner and partner-to-DRD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by DRD2-low versus DRD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DRD2→partner) and Y-score (partner→DRD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.538	-1.678	.006	.021	3	2
UCEC	Annexin-1 →	+0.426	+1.785	.007	.007	3	2
UCEC	Caspase-8 →	-0.181	-2.221	.017	.001	3	2
UCEC	ERK2 →	+0.128	+1.321	.028	.027	3	1
UCEC	JNK2 →	+0.168	+1.125	.005	.033	3	1
UCEC	MEK1 →	+0.510	+2.954	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

IGFBP2 by DRD2 expression — UCEC

Explore this box plot interactively →