DRD2

Across TCGA cell cohorts, DRD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,724 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DRD2-associated GO terms across cancer lineages are Regulation of locomotion involved in locomotory behavior, Adenylate cyclase-inhibiting dopamine receptor signaling pathway, and Peristalsis. Each is linked with DRD2 in more than 12 cancer types. Because this analysis shows association rather than direction, both DRD2-to-partner and partner-to-DRD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of locomotion involved in locomotory behavior grouped by DRD2-low versus DRD2-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DRD2→partner) and Y-score (partner→DRD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of locomotion involved in locomotory behavior →	-0.328	-1.679	<.001	<.001	3	13
LARGE_INTESTINE	Adenylate cyclase-inhibiting dopamine receptor signaling pathway →	-0.242	-1.513	<.001	<.001	3	12
LUNG_SCLC	Peristalsis →	+1.714	+2.871	<.001	<.001	3	12
OVARY	Cerebral cortex neuron differentiation →	-0.205	-0.293	<.001	.004	3	8
CNS	Positive regulation of neurotransmitter uptake →	-0.328	-1.763	.006	<.001	2	9
SKIN	Phospholipase C-activating dopamine receptor signaling pathway →	-0.388	-1.098	.002	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,724 associations by consensus.

Regulation of locomotion involved in locomotory behavior by DRD2 expression — LARGE_INTESTINE

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