DRD2

Across TCGA cell cohorts, DRD2 mutation is significantly associated with the RNA expression of many other genes, with 95 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DRD2-associated genes across cancer lineages are ANKRD66, OR52J3, and ANKRD63. Each is linked with DRD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DRD2-to-partner and partner-to-DRD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANKRD66 grouped by DRD2-low versus DRD2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DRD2→partner) and Y-score (partner→DRD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ANKRD66 →	+0.016	+4.237	<.001	.006	3	2
SKIN	OR52J3 →	+0.046	+4.437	<.001	.004	3	2
SKIN	ANKRD63 →	+0.084	+3.684	<.001	.009	3	2
PANCREAS	COL6A5 →	+0.011	+4.491	.002	.003	3	1
PANCREAS	MYH6 →	+0.007	+5.584	<.001	<.001	3	1
PANCREAS	CLLU1-AS1 →	+0.043	+4.011	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 95 associations by consensus.

ANKRD66 by DRD2 expression — PANCREAS

Explore this box plot interactively →