Across TCGA patient cohorts, DRD1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DRD1-associated genes across cancer lineages are eIF4E, Caspase-8, and Cyclin-E2. Each is linked with DRD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DRD1-to-partner and partner-to-DRD1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DRD1→partner) and Y-score (partner→DRD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.152	+1.440	.038	.024	3	2
UCEC	Caspase-8 →	-0.264	-3.143	.002	<.001	3	2
UCEC	Cyclin-E2 →	+0.159	+1.916	.006	.009	3	2
SKCM	mTOR_pS2448 →	+0.150	+1.906	.039	.016	3	1
SKCM	AMPK_alpha →	+0.180	+1.906	.001	.016	3	1
SKCM	CDK1 →	+0.238	+1.874	<.001	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Exploration

DRD1 survival (RNA) · tumor vs normal (RNA) · all DRD1 data types