DRC3

Across TCGA patient cohorts, DRC3 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DRC3-associated genes across cancer lineages are eEF2, Caspase-7-cleavedD198, and EGFR_pY1068. Each is linked with DRC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DRC3-to-partner and partner-to-DRC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by DRC3-low versus DRC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DRC3→partner) and Y-score (partner→DRC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.408	+2.700	.011	.006	3	2
UCEC	Caspase-7-cleavedD198 →	+1.087	+2.479	<.001	.010	3	2
UCEC	EGFR_pY1068 →	-0.272	-2.700	.016	.006	3	1
UCEC	ERK2 →	+0.231	+3.459	.007	.005	3	1
UCEC	Lck →	+0.358	+2.000	<.001	.032	3	1
UCEC	MAPK_pT202_Y204 →	-0.512	-2.459	.015	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

eEF2 by DRC3 expression — UCEC

Explore this box plot interactively →