DRC1

Across TCGA patient cohorts, DRC1 mutation is significantly associated with the RNA expression of many other genes, with 2,130 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DRC1-associated genes across cancer lineages are LINC01072, RPL23AP82, and SDHB. Each is linked with DRC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DRC1-to-partner and partner-to-DRC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01072 grouped by DRC1-low versus DRC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DRC1→partner) and Y-score (partner→DRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LINC01072 →	+0.091	+1.903	.001	.002	3	3
UCEC	RPL23AP82 →	+0.339	+2.255	<.001	.001	3	3
UCEC	SDHB →	+0.362	+1.836	.001	.001	3	3
UCEC	PSMC3IP →	+0.504	+2.526	<.001	.001	3	3
UCEC	SKA1 →	+0.542	+3.606	.001	.001	3	3
UCEC	PPP2R2D →	+0.261	+1.857	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,130 associations by consensus.

LINC01072 by DRC1 expression — UCEC

Explore this box plot interactively →