DRC1

Across TCGA cell cohorts, DRC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,438 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DRC1-associated GO terms across cancer lineages are Macroautophagy, Negative regulation of myoblast fusion, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with DRC1 in more than 9 cancer types. Because this analysis shows association rather than direction, both DRC1-to-partner and partner-to-DRC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Macroautophagy grouped by DRC1-low versus DRC1-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DRC1→partner) and Y-score (partner→DRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Macroautophagy →	+0.036	+0.104	.001	.002	3	10
BREAST	Negative regulation of myoblast fusion →	+0.098	+0.223	.001	.008	3	10
BLOOD_Lymphoma	Negative regulation of syncytium formation by plasma membrane fusion →	+0.088	+0.075	<.001	<.001	3	10
BLOOD_Lymphoma	Regulation of myoblast fusion →	+0.088	+0.095	<.001	<.001	3	9
LUNG_SCLC	Process utilizing autophagic mechanism →	+0.047	+0.608	<.001	<.001	3	9
LUNG_SCLC	Autophagy →	+0.047	+0.608	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,438 associations by consensus.

Macroautophagy by DRC1 expression — LARGE_INTESTINE

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