DRC1

Across TCGA cell cohorts, DRC1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DRC1-associated genes across cancer lineages are MT4, OR13C4, and OPN1MW. Each is linked with DRC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DRC1-to-partner and partner-to-DRC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MT4 grouped by DRC1-low versus DRC1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DRC1→partner) and Y-score (partner→DRC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MT4 →	+0.172	+5.169	<.001	.005	3	1
BREAST	OR13C4 →	+0.039	+5.169	<.001	.005	3	1
BREAST	OPN1MW →	+0.049	+5.169	<.001	.005	3	1
LARGE_INTESTINE	SOX3 →	+0.044	+3.793	.002	.007	3	1
LARGE_INTESTINE	COX6A2 →	+0.082	+4.437	<.001	.004	3	1
LARGE_INTESTINE	TRDN →	+0.036	+4.054	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

MT4 by DRC1 expression — BREAST

Explore this box plot interactively →