DRAXIN

Across TCGA patient cohorts, DRAXIN mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DRAXIN-associated genes across cancer lineages are NF2, 14-3-3_beta, and EGFR_pY1068. Each is linked with DRAXIN in more than 1 cancer types. Because this analysis shows association rather than direction, both DRAXIN-to-partner and partner-to-DRAXIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF2 grouped by DRAXIN-low versus DRAXIN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DRAXIN→partner) and Y-score (partner→DRAXIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NF2 →	+0.231	+2.000	.008	.030	3	2
UCEC	14-3-3_beta →	-0.122	-1.893	.002	.016	3	1
UCEC	EGFR_pY1068 →	-0.293	-2.415	.003	.003	3	1
UCEC	Heregulin →	-0.139	-1.906	.005	.016	3	1
UCEC	JNK2 →	+0.281	+2.415	<.001	.003	3	1
UCEC	Myosin-IIa_pS1943 →	+0.202	+2.428	.015	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

NF2 by DRAXIN expression — UCEC

Explore this box plot interactively →