DRAM2

Across TCGA patient cohorts, DRAM2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DRAM2-associated genes across cancer lineages are eEF2, INPP4B, and IRS1. Each is linked with DRAM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DRAM2-to-partner and partner-to-DRAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by DRAM2-low versus DRAM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DRAM2→partner) and Y-score (partner→DRAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.393	+2.321	.028	.035	3	1
UCEC	INPP4B →	-0.496	-3.446	.002	.005	3	1
UCEC	IRS1 →	-0.237	-2.321	.022	.035	3	1
UCEC	MAPK_pT202_Y204 →	-0.510	-2.321	.030	.035	3	1
UCEC	14-3-3_epsilon →	+0.112	+3.009	.025	.019	3	1
UCEC	Src_pY527 →	-0.494	-2.321	.022	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

eEF2 by DRAM2 expression — UCEC

Explore this box plot interactively →