DRAM2

Across TCGA cell cohorts, DRAM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,627 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DRAM2-associated GO terms across cancer lineages are Regulation of tRNA catabolic process, Negative regulation of tRNA catabolic process, and Regulation of tRNA stability. Each is linked with DRAM2 in more than 10 cancer types. Because this analysis shows association rather than direction, both DRAM2-to-partner and partner-to-DRAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of tRNA catabolic process grouped by DRAM2-low versus DRAM2-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DRAM2→partner) and Y-score (partner→DRAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Regulation of tRNA catabolic process →	-0.102	-0.946	.009	<.001	3	11
URINARY_TRACT	Negative regulation of tRNA catabolic process →	-0.102	-0.946	.009	<.001	3	11
URINARY_TRACT	Regulation of tRNA stability →	-0.102	-0.946	.009	<.001	3	11
URINARY_TRACT	tRNA stabilization →	-0.102	-0.946	.009	<.001	3	11
KIDNEY	Zinc ion import into Golgi lumen →	+0.123	+0.997	<.001	<.001	3	11
PANCREAS	rRNA metabolic process →	-0.070	-0.752	.008	.005	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,627 associations by consensus.

Regulation of tRNA catabolic process by DRAM2 expression — URINARY_TRACT

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