DRAIC

Across TCGA pan-cancer cohorts, DRAIC RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of DRAIC’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where DRAIC RNA is repressed in tumor relative to normal tissue. In most cancer types DRAIC is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and BRCA are the cancer types where DRAIC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DRAIC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Female	II,III,IV	−3.324	<.001	11	view →
KICH	All	II,III,IV	−2.238	<.001	8	view →
BRCA	All	III,IV	+1.188	<.001	8	view →
COAD	All	IV	−1.434	<.001	7	view →
KIRC	Female	All	+1.347	.002	6	view →
LUSC	Male	II,III,IV	−0.438	<.001	6	view →
READ	All	All	−1.357	.017	3	view →
LUAD	All	All	+0.786	<.001	3	view →
PRAD	All	All	+1.998	<.001	2	view →
CHOL	Male	All	−1.343	.027	2	view →
LIHC	All	All	+0.868	.002	2	view →
STAD	Female	III,IV	−0.315	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

DRAIC–KIRP

Open the KIRP breakdown →