DR1

Across TCGA patient cohorts, DR1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DR1-associated genes across cancer lineages are 14-3-3_beta, FoxM1, and ACVRL1. Each is linked with DR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DR1-to-partner and partner-to-DR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by DR1-low versus DR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DR1→partner) and Y-score (partner→DR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.075	-2.295	.032	.033	3	1
UCEC	FoxM1 →	+0.234	+1.440	.009	.024	3	1
UCEC	ACVRL1 →	-0.117	-1.658	.013	.021	3	1
UCEC	MEK1 →	+0.495	+3.807	<.001	<.001	3	1
UCEC	Notch1 →	+0.141	+1.736	.003	.007	3	1
UCEC	p27_pT198 →	+0.076	+1.807	.039	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

14-3-3_beta by DR1 expression — UCEC

Explore this box plot interactively →