DR1

Across TCGA cell cohorts, DR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,101 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DR1-associated GO terms across cancer lineages are Negative regulation of RNA polymerase II transcription preinitiation complex assembly, RISC complex assembly, and Positive regulation of nuclear cell cycle DNA replication. Each is linked with DR1 in more than 17 cancer types. Because this analysis shows association rather than direction, both DR1-to-partner and partner-to-DR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of RNA polymerase II transcription preinitiation complex assembly grouped by DR1-low versus DR1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DR1→partner) and Y-score (partner→DR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of RNA polymerase II transcription preinitiation complex assembly →	+0.147	+0.992	<.001	<.001	3	18
OVARY	RISC complex assembly →	+0.108	+0.686	.002	.001	3	15
PANCREAS	Positive regulation of nuclear cell cycle DNA replication →	+0.139	+0.757	.001	<.001	3	15
BREAST	Regulation of RNA polymerase II transcription preinitiation complex assembly →	+0.146	+1.307	<.001	<.001	3	14
PANCREAS	Phosphatidylinositol metabolic process →	+0.055	+0.756	.002	.009	3	14
LARGE_INTESTINE	Microtubule polymerization →	+0.134	+1.180	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,101 associations by consensus.

Negative regulation of RNA polymerase II transcription preinitiation complex assembly by DR1 expression — URINARY_TRACT

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