DQX1

Across TCGA patient cohorts, DQX1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DQX1-associated genes across cancer lineages are EGFR_pY1068, JNK_pT183_Y185, and Notch1. Each is linked with DQX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DQX1-to-partner and partner-to-DQX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by DQX1-low versus DQX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DQX1→partner) and Y-score (partner→DQX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.294	-3.584	.004	.002	3	2
UCEC	JNK_pT183_Y185 →	-0.229	-2.000	<.001	.030	3	2
UCEC	Notch1 →	+0.200	+2.321	<.001	.006	3	2
UCEC	CD49b →	-0.319	-3.156	.006	.018	3	2
UCEC	Heregulin →	-0.103	-1.807	.043	.027	3	1
UCEC	ACVRL1 →	-0.154	-2.308	.006	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

EGFR_pY1068 by DQX1 expression — UCEC

Explore this box plot interactively →