DQX1

Across TCGA cell cohorts, DQX1 mutation is significantly associated with the RNA expression of many other genes, with 187 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DQX1-associated genes across cancer lineages are GCAT, BAG2, and WRAP73. Each is linked with DQX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DQX1-to-partner and partner-to-DQX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GCAT grouped by DQX1-low versus DQX1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DQX1→partner) and Y-score (partner→DQX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GCAT →	+1.703	+3.212	<.001	.006	3	1
LARGE_INTESTINE	BAG2 →	+1.064	+3.212	.002	.006	3	1
LARGE_INTESTINE	WRAP73 →	+0.604	+3.212	.001	.006	3	1
LARGE_INTESTINE	TSFM →	+0.565	+3.212	<.001	.006	3	1
LARGE_INTESTINE	METTL8 →	+0.853	+3.212	<.001	.006	3	1
LARGE_INTESTINE	CHIA →	+0.027	+2.760	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 187 associations by consensus.

GCAT by DQX1 expression — LARGE_INTESTINE

Explore this box plot interactively →