DPYSL5

Across TCGA pan-cancer cohorts, DPYSL5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DPYSL5 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DPYSL5 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DPYSL5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and GBM show a favorable association.

HNSC, PDAC, and GBM are the cancer types where DPYSL5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.884	0.620	.009	45	view →
PDAC	DFS	Median	All	0.768	1.000	.014	24	view →
GBM	OS	Quartile	All	0.982	0.662	.005	10	view →
LSCC	DFS	Median	All	0.929	0.568	.010	5	view →
CCRCC	OS	Median	All	0.266	0.855	.010	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DPYSL5–HNSC (OS)

Open the HNSC breakdown →