DPYSL5

Across TCGA patient cohorts, DPYSL5 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPYSL5-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and eIF4E. Each is linked with DPYSL5 in more than 2 cancer types. Because this analysis shows association rather than direction, both DPYSL5-to-partner and partner-to-DPYSL5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by DPYSL5-low versus DPYSL5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPYSL5→partner) and Y-score (partner→DPYSL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.359	+2.222	.002	.009	3	3
UCEC	Caspase-7-cleavedD198 →	+0.522	+1.505	.008	.034	3	3
UCEC	eIF4E →	+0.172	+3.472	.014	.002	3	2
UCEC	JNK2 →	+0.289	+3.727	<.001	<.001	3	2
UCEC	MEK1 →	+0.386	+2.584	.001	<.001	3	2
UCEC	TFRC →	+0.523	+2.700	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

ASNS by DPYSL5 expression — UCEC

Explore this box plot interactively →