DPYSL4

Across TCGA patient cohorts, DPYSL4 mutation is significantly associated with the RNA expression of many other genes, with 2,564 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPYSL4-associated genes across cancer lineages are PPP2R5E, LIN52, and RFC5. Each is linked with DPYSL4 in more than 3 cancer types. Because this analysis shows association rather than direction, both DPYSL4-to-partner and partner-to-DPYSL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP2R5E grouped by DPYSL4-low versus DPYSL4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPYSL4→partner) and Y-score (partner→DPYSL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PPP2R5E →	+0.564	+3.335	.003	.005	3	4
UCEC	LIN52 →	+0.307	+2.042	.004	.004	3	4
UCEC	RFC5 →	+0.442	+2.425	<.001	.001	3	4
UCEC	SHQ1 →	+0.307	+2.490	.004	.001	3	4
LUAD	HROB →	+1.039	+3.471	<.001	.002	3	3
LUAD	ADH1C →	-1.919	-3.447	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,564 associations by consensus.

PPP2R5E by DPYSL4 expression — COAD

Explore this box plot interactively →