DPYSL4

Across TCGA patient cohorts, DPYSL4 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPYSL4-associated genes across cancer lineages are Cyclin-B1, TFRC, and TIGAR. Each is linked with DPYSL4 in more than 3 cancer types. Because this analysis shows association rather than direction, both DPYSL4-to-partner and partner-to-DPYSL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by DPYSL4-low versus DPYSL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPYSL4→partner) and Y-score (partner→DPYSL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.574	+2.415	.002	.002	3	4
UCEC	TFRC →	+0.563	+1.765	.001	.013	3	3
UCEC	TIGAR →	+0.127	+1.833	.014	.002	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.501	-2.906	.001	.001	3	2
COAD	A-Raf_pS299 →	-0.238	-3.000	.006	.035	3	2
UCEC	FOXO3a_pS318_S321 →	-0.104	-1.405	.014	.043	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Cyclin-B1 by DPYSL4 expression — UCEC

Explore this box plot interactively →