DPYSL3

Across TCGA patient cohorts, DPYSL3 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPYSL3-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and MEK1. Each is linked with DPYSL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both DPYSL3-to-partner and partner-to-DPYSL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DPYSL3-low versus DPYSL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPYSL3→partner) and Y-score (partner→DPYSL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.677	+2.019	<.001	.001	3	3
UCEC	14-3-3_beta →	-0.094	-2.388	.002	.002	3	2
UCEC	MEK1 →	+0.436	+2.115	<.001	<.001	3	2
UCEC	Notch1 →	+0.192	+2.183	<.001	.001	3	2
UCEC	Rab25 →	-0.385	-2.321	<.001	.005	3	2
UCEC	Shc_pY317 →	-0.148	-1.662	.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Caspase-7-cleavedD198 by DPYSL3 expression — UCEC

Explore this box plot interactively →