DPYSL3

Across TCGA cell cohorts, DPYSL3 mutation is significantly associated with the RNA expression of many other genes, with 132 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DPYSL3-associated genes across cancer lineages are OR4M1, LCE2C, and IQCF5. Each is linked with DPYSL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPYSL3-to-partner and partner-to-DPYSL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4M1 grouped by DPYSL3-low versus DPYSL3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPYSL3→partner) and Y-score (partner→DPYSL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR4M1 →	+0.008	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	LCE2C →	+0.025	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	IQCF5 →	+0.072	+4.189	<.001	.002	3	1
OVARY	PPY →	+0.212	+4.029	<.001	.009	3	1
OVARY	LYZL1 →	+0.042	+4.990	<.001	.001	3	1
OVARY	SPATA48 →	+0.010	+4.807	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 132 associations by consensus.

OR4M1 by DPYSL3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →