DPYSL2

Across TCGA patient cohorts, DPYSL2 mutation is significantly associated with the RNA expression of many other genes, with 2,701 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPYSL2-associated genes across cancer lineages are MRPL16, COQ3, and RPARP-AS1. Each is linked with DPYSL2 in more than 3 cancer types. Because this analysis shows association rather than direction, both DPYSL2-to-partner and partner-to-DPYSL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL16 grouped by DPYSL2-low versus DPYSL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPYSL2→partner) and Y-score (partner→DPYSL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL16 →	+0.220	+1.330	.008	.007	3	4
UCEC	COQ3 →	+0.408	+1.776	<.001	<.001	3	4
UCEC	RPARP-AS1 →	+0.343	+1.562	.001	.002	3	3
UCEC	PKN3 →	+0.615	+2.412	<.001	<.001	3	3
UCEC	APEH →	+0.345	+1.253	.003	.006	3	3
UCEC	NDUFAF2 →	+0.499	+2.402	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,701 associations by consensus.

MRPL16 by DPYSL2 expression — UCEC

Explore this box plot interactively →