DPYSL2

Across TCGA cell cohorts, DPYSL2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DPYSL2-associated genes across cancer lineages are PABPC1L2B, LGI3, and ABCG4. Each is linked with DPYSL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPYSL2-to-partner and partner-to-DPYSL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PABPC1L2B grouped by DPYSL2-low versus DPYSL2-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPYSL2→partner) and Y-score (partner→DPYSL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PABPC1L2B →	+0.099	+4.736	.009	.009	3	1
LARGE_INTESTINE	LGI3 →	+0.436	+3.392	<.001	.003	3	1
LARGE_INTESTINE	ABCG4 →	+0.257	+3.451	.001	.005	3	1
LARGE_INTESTINE	FAM205A →	+0.027	+4.252	<.001	<.001	3	1
LARGE_INTESTINE	TMSB4Y →	+1.372	+2.819	<.001	.006	2	1
LARGE_INTESTINE	L3MBTL4 →	+0.657	+3.285	.002	.007	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

PABPC1L2B by DPYSL2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →