Across TCGA pan-cancer cohorts, DPYD mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated DPYD data layer compared with 22 for mass-spec protein and 9 for mutation status.
The strongest signal is observed in colon adenocarcinoma (COAD), where higher DPYD mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DPYD expression acts as an unfavorable survival marker.
COAD, PDAC, and GBM are the cancer types where DPYD mass-spec protein most reproducibly stratifies survival.
mass-spec protein survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.