Across TCGA pan-cancer cohorts, DPYD mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of DPYD’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DPYD mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types DPYD is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

COAD, LUAD, and PDAC are the cancer types where DPYD tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DPYD mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	−0.669	<.001	9	view →
LUAD	Female	All	+0.578	<.001	9	view →
PDAC	Male	All	+0.529	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: DPYD RNA expression & survival · all DPYD data types