Across TCGA patient cohorts, DPYD protein abundance is significantly associated with the RNA expression of many other genes, with 22,299 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DPYD-associated genes across cancer lineages are DSE, CD86, and SIGLEC9. Each is linked with DPYD in more than 9 cancer types. Because this analysis shows association rather than direction, both DPYD-to-partner and partner-to-DPYD results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPYD→partner) and Y-score (partner→DPYD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DSE →	+0.672	+0.607	<.001	<.001	3	10
OV	CD86 →	+1.046	+0.462	<.001	<.001	3	10
UCEC	SIGLEC9 →	+0.928	+0.687	<.001	<.001	3	10
GBM	ALOX5AP →	+1.046	+0.848	<.001	<.001	3	10
CCRCC	GPR84 →	+0.801	+0.492	<.001	<.001	3	10
OV	EMP3 →	+0.992	+0.550	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,299 associations by consensus.

Exploration

DPYD survival (RNA) · tumor vs normal (RNA) · all DPYD data types