Across TCGA patient cohorts, DPYD mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPYD-associated genes across cancer lineages are C-Raf, Cyclin-B1, and Caspase-7-cleavedD198. Each is linked with DPYD in more than 4 cancer types. Because this analysis shows association rather than direction, both DPYD-to-partner and partner-to-DPYD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPYD→partner) and Y-score (partner→DPYD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.134	+1.125	.001	.033	3	5
UCEC	Cyclin-B1 →	+0.699	+4.169	<.001	<.001	3	4
UCEC	Caspase-7-cleavedD198 →	+0.445	+1.522	.013	.017	3	3
UCEC	Caveolin-1 →	-0.520	-3.906	.017	<.001	3	3
UCEC	EGFR_pY1068 →	-0.241	-1.523	.001	.006	3	2
UCEC	FoxM1 →	+0.188	+1.530	.016	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

Exploration

DPYD survival (RNA) · tumor vs normal (RNA) · all DPYD data types