Across TCGA cell cohorts, DPYD mutation is significantly associated with the RNA expression of many other genes, with 246 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DPYD-associated genes across cancer lineages are KRT72, OR56A4, and OR56A3. Each is linked with DPYD in more than 1 cancer types. Because this analysis shows association rather than direction, both DPYD-to-partner and partner-to-DPYD results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPYD→partner) and Y-score (partner→DPYD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KRT72 →	+0.020	+4.450	.001	.004	3	2
KIDNEY	OR56A4 →	+0.006	+5.000	<.001	.005	3	1
KIDNEY	OR56A3 →	+0.026	+5.000	<.001	.005	3	1
KIDNEY	CD300E →	+0.006	+5.000	<.001	.005	3	1
KIDNEY	CTXND2 →	+0.140	+5.000	<.001	.005	3	1
SKIN	MC3R →	+0.112	+2.621	.003	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 246 associations by consensus.

Exploration

DPYD survival (RNA) · tumor vs normal (RNA) · all DPYD data types