DPY30

Across TCGA pan-cancer cohorts, DPY30 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of DPY30’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DPY30 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DPY30 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRC, and BLCA are the cancer types where DPY30 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DPY30 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.987	<.001	12	view →
KIRC	Female	IV	+0.845	<.001	12	view →
BLCA	All	All	+0.813	<.001	12	view →
LIHC	Male	II,III,IV	+1.115	<.001	9	view →
LUAD	Male	II,III,IV	+0.853	<.001	9	view →
COAD	Female	II,III,IV	+0.724	<.001	8	view →
KICH	Female	II,III,IV	−1.640	<.001	7	view →
LUSC	Female	All	+0.985	<.001	6	view →
BRCA	All	III,IV	+0.883	<.001	6	view →
STAD	All	II,III,IV	+0.546	<.001	6	view →
UCEC	All	All	+0.469	.007	6	view →
KIRP	All	II,III,IV	+0.431	.010	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

DPY30–HNSC

Open the HNSC breakdown →