DPY30

Across TCGA pan-cancer cohorts, DPY30 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of DPY30’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where DPY30 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types DPY30 is over-expressed in tumor.

LSCC, LUAD, and PDAC are the cancer types where DPY30 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DPY30 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	+0.812	<.001	9	view →
LUAD	Male	All	+0.719	<.001	9	view →
PDAC	Male	All	+1.335	<.001	7	view →
COAD	Female	All	+0.349	.002	4	view →
OV	All	All	+0.988	<.001	2	view →
HNSC	Male	IV	+0.314	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

DPY30–LSCC

Open the LSCC breakdown →