DPY19L4

Across TCGA patient cohorts, DPY19L4 mutation is significantly associated with the RNA expression of many other genes, with 2,703 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPY19L4-associated genes across cancer lineages are NRBF2P3, MIR6803, and JOSD1. Each is linked with DPY19L4 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPY19L4-to-partner and partner-to-DPY19L4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NRBF2P3 grouped by DPY19L4-low versus DPY19L4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPY19L4→partner) and Y-score (partner→DPY19L4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NRBF2P3 →	+0.119	+2.936	<.001	.005	3	2
UCEC	MIR6803 →	+0.086	+3.954	<.001	.006	3	2
UCEC	JOSD1 →	+0.444	+2.392	.001	<.001	3	2
UCEC	MIEF1 →	+0.469	+2.807	.001	.003	3	2
UCEC	L3MBTL2 →	+0.388	+2.403	<.001	<.001	3	2
UCEC	ACO2 →	+0.677	+2.016	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,703 associations by consensus.

NRBF2P3 by DPY19L4 expression — SKCM

Explore this box plot interactively →