DPY19L4

Across TCGA patient cohorts, DPY19L4 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPY19L4-associated genes across cancer lineages are eEF2, FoxM1, and JNK_pT183_Y185. Each is linked with DPY19L4 in more than 2 cancer types. Because this analysis shows association rather than direction, both DPY19L4-to-partner and partner-to-DPY19L4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by DPY19L4-low versus DPY19L4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPY19L4→partner) and Y-score (partner→DPY19L4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eEF2 →	+0.620	+2.824	.001	.034	3	3
UCEC	FoxM1 →	+0.233	+1.807	.029	.027	3	2
UCEC	JNK_pT183_Y185 →	-0.237	-2.986	<.001	.001	3	2
UCEC	Notch1 →	+0.221	+2.469	<.001	.010	3	2
UCEC	Paxillin →	+0.297	+3.335	.005	.005	3	2
UCEC	PCNA →	+0.284	+3.459	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

eEF2 by DPY19L4 expression — SKCM

Explore this box plot interactively →